Animal Models of Neurological Disease, II Metabolic by Alan A. Boulton, Glen B. Baker, Roger F. Butterworth

By Alan A. Boulton, Glen B. Baker, Roger F. Butterworth

To the Animal types Volumes This and a number of other volumes within the Neuromethods sequence will describe a few animal types of neuropsychiatric problems. as a result of expanding public trouble over the moral therapy of animals in examine, we felt it incumbent upon us to incorporate this normal preface to those volumes with a purpose to point out why we expect extra - seek utilizing animals is important and why animal types of psychiatric issues, specifically, are so vital. We realize that animals may still simply be used whilst appropriate choices aren't to be had. we expect it self-e- dent, even though, that people can merely be experimented upon in seriously proscribed situations and substitute seasoned- dures utilizing telephone or tissue tradition are insufficient in any versions requiring tests of behavioral swap or of advanced in vivo techniques. notwithstanding, whilst the misery, ache, or discomfort to the animals outweighs the predicted profits for human welfare, then the learn isn't really moral and shouldn't be performed. it really is principal that every person researcher study his/her personal study from a severe ethical viewpoint - fore undertaking it, bearing in mind the animals’ welfare in addition to the predicted earnings. in addition, as soon as a call to continue with examine is made, it's the researcher’s accountability to make sure that the animals’ w- fare is of major challenge by way of acceptable housing, feeding, and greatest relief of any uncomfortable or distressing results of the experimental stipulations, and that those stipulations endure widespread formalized tracking.

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Extra info for Animal Models of Neurological Disease, II Metabolic Encephalopathies and Epilepsies

Sample text

The concept of etiologic validity is especially important in testing hypotheses about genetic or environmental risk factors associated with psychopathology, in other words, when the overall objective of the study is to determine whether and how certain factors lead to disease. Clearly, construct and etiologic validity of an animal model are difficult to establish, requiring both a clear theory of the biologic roots of the human condition being modeled as well as constant interchange of information between investigators studying the human condition and those involved in animal modeling.

Biol. Psychiatry 35, 1376–1382. , 2011. Disrupted-in-schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling. Proc. Natl. Acad. Sci. A. 108 (14), 5861–5866. , 1999. Genetics of mouse behavior: interactions with laboratory environment. Science 284, 1670–1672. , 2013. The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: a meta-analysis of direct comparisons. World Psychiatry 12, 137–148. , 2011. Disc1 regulates both β-catenin-mediated and noncanonical Wnt signaling during vertebrate embryogenesis.

According to Van der Staay (2006), if the model fulfills the criterion of generalizability, it most likely demonstrates construct validity; if not, it is considered to lack relevance. In the model validation process, Van der Staay (2009) emphasizes the process of replication for determining the reliability and generalizability of a model. 25 observed and described, an attempt should be made to replicate them in a separate experiment, following the original procedures as closely as possible. This process, called direct replication, serves to verify and confirm the original results, and to eliminate the possibility that the original observation was a false positive.

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