Cancer Biology (3rd Edition) by Roger J.B. King, Mike W. Robins

By Roger J.B. King, Mike W. Robins

Presents a transparent, concise and authoritative advent to the organic ideas that underlie the factors and therapy of melanoma.

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Extra info for Cancer Biology (3rd Edition)

Example text

Both familial types occur before age 50 years, earlier than the sporadic cancers. 11 Major gene changes during colorectal carcinogenesis. 4). 11). Benign adenomas are classified largely by size and degree of cellular abnormality, while ‘carcinoma in situ’ is not a term that is applied to colorectal cancer. The availability of tissue from each of these stages has allowed analysis of DNA alterations at each stage, and a picture has been built up to describe 26 .. 1 Major gene changes involved in colorectal cancers.

Molecular biologists think in terms of discrete mutational events (model 3). Progression would be equated to change C in model 3. Model 4 describes the sequence of histological changes observed in human and animal tumours, with progression referring to stages beyond in situ carcinoma. Data so derived have emphasised the multifactorial nature of cancer aetiology, the multiple changes required to generate a cancer and the fact that changes continue to occur in established tumours. Animal studies Carcinogenesis: initiation and promotion Percival Potts, an eighteenth-century surgeon, first noted that young male chimneysweeps had a high incidence of scrotal cancer.

Silver, A. and Tomlinson, I. (2004) An update on the genetics of colorectal cancer. Hum Mol Genet 13, R177–R185. W. and Vogelstein, B. (1997) Cancer-susceptibility genes: gatekeepers and caretakers. Nature 386, 761–762. R. and Folkman, J. (1991) Tumour angiogenesis and metastasis: correlation in invasive breast carcinoma. N Engl J Med 324, 1–8. 31 .. qxd 3/04/2006 08:39 Page 32 3 KEY POINTS Pathology: defining a neoplasm ● Tissue and cell architecture are used to decide whether a growth is malignant.

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