Cell Migration: Signalling and Mechanisms (Translational by Frank Entschladen, Kurt S. Zanker

By Frank Entschladen, Kurt S. Zanker

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Extra resources for Cell Migration: Signalling and Mechanisms (Translational Research in Biomedicine, Vol. 2)

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The maintenance of polarity is essential for all movement. Polarity is achieved by the differential recruitment of chemoattractant and specific adhesion receptors (chemokine and integrin receptors) at the front of the cell, where actinrich structures such as filopodia, pseudopodia and the leading lamella protrude (fig. 2). In contrast, the microtubule-organizing center (MTOC), Golgi apparatus (GA) and associated vesicles are directed backwards to the uropod (fig. 2). Much work is Endothelial cells Blood flow UP LE Tethering and rolling Firm adhesion and docking structure Polarization Migration Gradient origin Diapedesis Fig.

22 Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, Kelly K, Takuwa Y, Sugimoto N, Mitchison T, Bourne HR: Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 2003;114:201–214. 23 Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW: The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 1999;97:221–231. 24 Van Rheenen J, Condeelis J, Glogauer M: A common cofilin activity cycle in invasive tumor cells and inflammatory cells.

Expert Opin Biol Ther 2008;8:1797–1804. 25 Broxmeyer HE, Orschell CM, Clapp DW, Hangoc G, Cooper S, Plett PA, Liles WC, Li X, GrahamEvans B, Campbell TB, Calandra G, Bridger G, Dale DC, Srour EF: Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med 2005;201:1307–1318. 26 Lapidot T: Mechanism of human stem cell migration and repopulation of NOD/SCID and B2mnull NOD/SCID mice. The role of SDF-1/CXCR4 interactions. Ann NY Acad Sci 2001;938:83–95.

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