Contemporary Biomaterials by John W. Boretos

By John W. Boretos

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However, one of the concerns of nephrologists is the lack of transfer of molecules in the range of 5,000 to 10,000 microns, a process that is very inefficient in dialyzers using currently available membranes. Other kinds of problems exist that are detrimental to the development of biomaterials for the future. One of these is the problem of legislative or regulatory constraints as set by the Medical Device Amendment of 1976. Another problem has to do with the judicial process. The past few years have seen an increased application of the doctrine of strict liability.

The suture industry has introduced more rapidly and to a greater extent new biomaterials than any other industry. 4 Sutures also illustrate a third fundamental consideration of biomaterials; namely, form. Sutures, being cylindrical, have a small volume to surface ratio. The total mass is relatively small compared to the volume of tissue surrounding it and this relation may contribute to the lack of problems with most sutures regardless of the material in the absence of infection. Another example where form or the geometry of the device may have had a biologic influence is the intrauterine contraceptive appliance.

Joist, J. , Burrows, S. , McKnight, R. B. Quantification of wear, hemolysis and coagulation deficits in patients with Beall mitral valves. Circulation Suppl. 56:139-143, 1977. (6) Clark, R. , Swanson, W. , Kardos, J. , Hagen, R. W. and Beauchamp, R. A. Durability of prosthetic heart valves. Ann. Thorac. Surg. 26:323-335, 1978. , Ill, Kouchoukos, N. , Karp, R. , Pacifico, A. D. and Kirklin, J. W. Late stenosis of Starr-Edwards cloth covered protheses. Ann. Thorac. Surg. 20:249-255, 1975. (8) Pierrie, W.

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