Current Topics in Microbiology and Immunology by Ellen G. Strauss, James H. Strauss (auth.), M. Cooper, P. H.

By Ellen G. Strauss, James H. Strauss (auth.), M. Cooper, P. H. Hofschneider, H. Koprowski, F. Melchers, R. Rott, H. G. Schweiger, P. K. Vogt, R. Zinkernagel (eds.)

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5 14 14 None Requirement for functional nucleus Morphogenesis only 0 Polycistronic messages (n) 0 5 Transcriptsb (n) 6-7 8 8 8 RNA in genome (n) 16-18 12 Genome (kb) } 10-12 } NDV, s,n

Kolakovsky, personal communication) Influenza A Influenza B Influenza C Orthomyxovirus Morbillivirus Pneumovirus Genera Family Table 3. Negative strand viruses w [Il [Il ~ q- Vl ~ ..... 1 Rhabdoviruses The family Rhabdoviridae contains a large number of viruses which share distinct biochemical and morphological characteristics and infect many different hosts (reviewed in Wagner 1975; Bishop and Smith 1977; Matthews 1982). The virions are bulletshaped or bacilliform, and their distinctive shape makes them useful markers in electron microscopy for a variety of experiments.

Ghosh et al. 1981) which is essential for infectivity of the RNA (Veerisetty and Sehgal 1979). The nonstructural proteins are two large proteins of molecular weights 105 K and 75 K, which share many tryptic peptides and are related by readthrough (Salerno-Rife et al. 1980; Mang et al. 1982). These genes are located near the 5' terminus of the genome. The capsid protein is translated from a subgenomic message which is coterminal with the 3' end of the genome (A. Ghosh et al. 1981). In addition, however, there is a smalll4-K polypeptide which appears to be translated from an internal cistron, but whether this protein is generated by processing ofa polyprotein precursor or by independent initiation of translation is unclear at present (Mang et al.

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