Diverse Effects of Hypoxia on Tumor Progression (Current by M. Celeste Simon

By M. Celeste Simon

Hypoxia, outlined as lowered oxygen stress, is a typical physiological phenomenon in either common embryonic improvement and malignancy development. even if critical hypoxia is mostly poisonous for either general tissue and tumors, neoplastic cells progressively adapt to lengthy hypoxia although extra genetic and genomic adjustments with a internet end result that hypoxia promotes tumor development and healing resistance. Hypoxia promotes melanoma development via regulating a number of facets of melanoma biology, together with radiotherapy resistance, metabolism, angiogenesis and invasion/migration

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Extra resources for Diverse Effects of Hypoxia on Tumor Progression (Current Topics in Microbiology and Immunology, Vol. 345)

Sample text

32 Adult Bone Marrow . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Hematopoietic Stem Cells, Mesenchymal Stem Cells and Endothelial Progenitors Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Fibrocyte Progenitor Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . .

2 Fibrocyte Progenitor Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Contribution of the Adult Bone Marrow to the Tumor Stroma . . . . . . . . . . . 34 3 Carcinoma Associated Fibroblasts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Definition of CAFs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Tissue Origin of CAFs and Molecular Mechanisms that Control Their Differentiation and Activity .

1 Definition of CAFs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Tissue Origin of CAFs and Molecular Mechanisms that Control Their Differentiation and Activity . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Regulation of Tumor Initiation, Progression and Metastasis by CAFs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 4 Tumor Hypoxia and CAFs .

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